Simparica is pretty new in England and it seems they are trialling it. She's pacing and wants to eat grass. This medication is generally well tolerated in most pets. He doesn't seem to be throwing up as much anymore, he did several times throughout the night though. I will never give another dose to him! This medication works within the first few hours after administration to kill fleas present on your dog, and is dosed by weight, so it is important to use the correct-sized medication for your pet. Saturday he started up the drinking again and threw up his breakfast. None of our pets did they were healthy. I called the vet and she gave me anitdiarrhea medicine. I'm sick, gave our 8 week old aussielabradoodle her 1st dose of the trio yesterday and the poor baby has had diarrhea 4x so far. Conclusion These include vomiting, diarrhea, lethargy, inappetence, itching, and, very . In clinical trials, vomiting and diarrhea were the most frequently reported adverse reactions. He said it would take care of ticks and Trifexis doesn't. Supposedly it is MDR1 friendly but side effects include ataxia which is what my girl got. She is scared of her own shadow, walks into things at times, trips and stumbles, has become very timid, stares at the wall and has to have either me or my husband in sight at all times. Come to find out Akita blood platelets can explode in storage causing hi readings. The only thing the vet told me was that his ATL liver enzyme levels were just slightly high (170) and it wasn't a concern and we could just do another blood test at his next check-up. I wish I would have came across this before I gave my healthy 9 month old puppy this medication two days ago. I was giving my 70 lb golden doodle Trifexus, for nearly 2 years until suddenly he refused to eat it. I took her home. As of today, Sadie's ability to eventually meet the strict certification requirements in that pursuit, remains guarded, although her progress prior to this event had been stellar. #JusticeforCassie My thoughts and prayers are with you all as I go through the same thing with my beautiful Cassie girl. I called the vet and they said it was likely brought on by stress. About 2 weeks later he had tremors, drooling, lethargic, uncoordinated, vomiting and was touch and go for a couple days. This excerpt is from the healthline website and in reference to humans "GABA is considered an inhibitory neurotransmitter because it blocks, or inhibits, certain brain signals and decreases activity in your nervous system. Will NEVER give this to my dog again. This time I am seeing a little blood or tissue in her stool. Bella is a very anxious dog and is my husbands shadow. Thank you for this information. He started having skin issues that the vet said were allergic reactions probably due to environmental things. The vet came and picked her up and cut her opened and said and told me she could anything wrong with her so it was either she was poisoned or it was a neurological disorder. Not known if there be permanent after-effects. Not sure what effects he will continue to have. RELATED: Signs Your Dog Might Be Having a Seizure. Fortunately for conscientious dog moms and dads, Simparica offers a once-a-month chewable treatment that is FDA-approved and safe for Fido, taking the guesswork out of fighting fleas and ticks. 4.3 4.3 out of 5 stars (34,534) $39.98 $ 39. I'm so glad I found this forum, it confirmed my instincts that this drug is very harmful. And now I'm upset with myself for giving this to my dog without doing research. My dog has been on simpatico trio for 5 months .. and still got a deer tick .. My sweet, funny, smart as can be baby girl died on 9/26/20. It is like night and day compared to her regular personality or demeanor. What You Need to Know About the Lyme Vaccine for Dogs. Hi, we did a spinal tap and MRI, its not viral or bacterial, its called steroid responsive meningitis which essentially is the meninges inflaming on their own, but if you look in this thread youll see others reporting similar symptoms/diagnosis so I do think Simparica trio triggered/caused it. My vet recommended this for my puppy, he is now lethargic, has blood in stool, and can hardly stay awake. its only been about 4 days since and its been a steady decline. around 12 years She grabs and won't let go. I started crying carrying his body to my husband . For Instance he has never liked grooming, I brushed him out last night and he slept through the whole thing. However, besides being nervous over the diarrhea, I am petrified about all of these people talking about seizures. This is happening now and she is still nowhere near 100% but I am hopeful that she will eventually fully recover. I have an appointment this Wednesday but not sure if Im going to keep it if the cough will go away eventually. Are there any side effects to Simparica Trio? They have become so bad that she cries and whimpers any time she is laying down. So I started searching and came across this blog and my heart just sank. By June 7th, she had a rash over most of her body, itching and biting herself to bloody raw spots. I have had German Shepherds for 40 yrs. I just want to cry! - she's had several episodes since then. This happened the same to my dog.. how si going now with your pet? These are classic neurological symptoms, exactly what our Pickles had before she passed. Never ever again with this med for him. Next day she seemed different, standing slightly strangely. After being ingested by a dog, sarolaner is distributed throughout the body. Im switching back to the protection he used before Simparica Trio. Since she is young, the vet started us with Keppra. Blood work + urine sample. At the vet today, I bought a single dose of Simparica Trio to try instead of Trifexis and Combogaurd, because they seem less tolerated by her now that she is older. Like many of you, I was unsure about the cause. Other alternative drugs are likely to offer poorer protection. I am hopeful he will make it through the next few weeks. Hes been on it for six months. Your veterinarian is the best source of information and will help you choose the right product for your dog and your budget. Overly anxious. I gave my six-year-old dog SIM perica because the combo guard was on back order. My dog has had 3 seizures in the past from wearing a flea collar. The term off-label or extra-label use means that a medication is used in a way or in a particular species that is not specified on the medication label. now seizures daily on all sorts of meds for it and the cost with medications to try and control seizures and vet visits and mainly seeing my once healthy playful full of life pups having seizures daily even in her sleep breaks my damn heart !!!!!!!!!!!!!! I would NEVER recommend this medication. I rescued a dog that had a light case of heartworms. But today she isnt eating well, had a bout of diarrhoea and is very tired. Please think these things through before subjecting your pet to internal insecticides. Side effects with Simparica are not common. We have been gradually increasing the dose but it hasnt helped. Drinking water and peeing excessively. This dog was my partner and friend. A few hours later, he began vomiting nonstop. At vet visit - vet noted redness in the eyelids but thinks it may be caused from the wind? I bought chicken last night he ate some of that . In isolated cases, however, dogs displayed more serious reactions such as tremors, muscle twitching, and seizures. The costs associated with these two products are roughly the same. It is recommended that all pets be tested for existing heartworm infection prior to starting treatment with Simparica Trio. The following morning he had another small seizure. She does have history of seizures. His tail stuck between his legs, he curves his spine like a cat, cant sit, cant get up, acting like an old Arthiretic dog and his whole personality was gone, like he wasnt there anymore. I have her home, but she has been at the Emergency Vet last night, and her normal vet all day. They gave him IV glucose to raise his Potassium level. And has been for about 3 weeks. The excerpts below from the manufacturers' Prescribing . Never had them ever and she's only 3 1/2 yrs old. She was being seen by her regular vet and was put on antibiotics. Will it get worse Will he get better? Nothing stopped the seizures and our Pickles passed away after just a few months of symptoms. How can they put something that can cause this level of damage on the market and how do vets not even tell us to monitor our pets or tell us what the risks are. She still coughs, sneezes and brings up lots of mucus. I removed it immediately She just tested positive for Lyme's. She has episodes where she seems very anxious and is hiding under car/tables/beds. i know this med did this to her , she was on for a year and half , i should never ever have listened to the vet and went with my gut, but again they assured me since she was healthy be very rare she would have side effects smdh and plus been in contract with the makers of this horrible medication they all should be ashamed of themselves!!!!!!!!!!! Our dog has not been given another dose. They are monitoring her. Because this ingredient works differently on invertebrates than mammals, however, Simparica for dogs has been proven safe during field trials. We have spent well over $5000.00 and upset about all the horror stories we are now hearing. She seems more anxious now and really attached to hubby. We contacted the company using the phone number supplied in the under in the box and shared our experience with the new drug. Oh how I wish I had know the side effects of this medicine I would never haven given it to her.. the company that makes this poison should be sued. I have read that Simparica may cause side effects including muscle tremors, diarrhea, lethargy, anorexia, otitis externa, hyperactivity, neurological side effects, seizures, convulsions, anxiety and skin irritation . Contact your vet if your dog misses a month or more of heartworm preventionyour dog might have become infected with heartworm larvae. The FDA considers this level to be "very rare". I have written to the parent company that makes Simparico (although I don't hold high hopes that I will ever hear from them) and also signed an online petition at Change. Never happened before. , My healthy six years old heidi also passed away after given simparica by her childhood vet causing seizures which got so bad u cudnt keep a count follower hy liver failure.dont give ny tick fleas medication orally. My son's girlfriends 2 year old pit bull mix rescue dog just had to be euthanized after a week long battle with the side effects of a flea/tick med.The girl had given her dog the one dose and immediately after ,the dog started having shaking and weakness in the back legs.Took her to an emergency vet.Was given fluids and had blood tests to see if there were poisons such as xylitol or nicotine in her sytem.No problems.$900 later..jsu 2-3 hours on fluids she was released with no answers.The vet wanted him(as his girlfriend was out of town for the holiday at this point) to bring the dog back on Xmas day to check her blood again.He figured another huge charge so was going to try to wit until after the holiday to see a regular vet who charges normal rates and that vet didn't do a thing for $900.00.The dog got progressively worse.Couldn't walk ,couldn't eat ,couldn't bark.Eyes were darting from side to side.Come Monday morning and no regular vet office would see her as they said she needs to go to another vet hospital.They wanted 2,600.00 from my son right up front for an overnight stay.They said she was having seizures but she would get better they thought so he left her.The next morning they said she needed more days in the hospital.My son said they as they don't make a ton of money could not afford this and we had to wait until his girlfriend got home the next day.He wanted to take the dog home.They said they would keep the dog for free for 12 hours..Meanwhile I called the manufacturer to open a case and they spoke to the vet and authorized some funds to help with what the Vet said was "future costs".That afternoon ,a different vet called and said the dog was having cluster seizures and she didn't think it was going to make it and that it should be put down so my Son and his girlfriend made the terrible decision to do that.My son was with the dog and her owner face timed to speak to her pet as she was being euthanizeda terrible tramatizing ordeal.Next thing you know,my son gets the ivoice from the Vet and it is over 5,000.00. 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