[Although] many patients have had to stay home from work for a day, because they feel like theyve gotten hit by a truck.. If you see a doctor for hemorrhoids, they might prescribe hydrocortisone that can be applied directly or in the form of a suppository. Some of our audience reported what seemed like regular vaccine side effects, but they were delayed fever, extreme fatigue, etc. 2022 Jun 7;157(6):844-851. doi: 10.1093/ajcp/aqab210. Local reactions were reported by the majority of vaccine recipients and at higher rates than placebo recipients. Others could be more systemic, such as low-grade fever, achiness, or fatigue that ranges from mild to severe. The authors have disclosed no conflicts of interest. COVID-19 vaccine, mRNA, monovalent (Moderna; Spikevax), is approved by the FDA as a primary (2-dose) series to prevent COVID-19 caused by the SARS-CoV-2 virus in people 18 years of age and older. Lockard Conley Research Fellowship in Benign Hematology (G.F.G.). S.C. has served on advisory boards for Alexion and Sanofi-Genzyme, and her institution has received research funding on her behalf from Takeda. Moderna's technology uses a nucleoside-modified messenger RNA (modRNA) compound codenamed mRNA-1273. Akrami M, Hosamirudsari H, Faraji N, Behnush B, Goudarzi F, Hesari E, Akbarpour S, Najafi A, Nateghi S. Indian J Med Microbiol. e Chills Grade 3: prevented daily activity and required medical intervention; Grade 4: required emergency room visit or hospitalization. Furthermore, S1 does not appear to bind erythrocytes (data not shown). See this image and copyright information in PMC. Hemorrhoids can be either inside your anus (internal) or under the skin around your anus (external). Accessibility The pharmacovigilance data also suggests that thrombocytopenia is also a frequent observation followed by mRNA CoViD vaccines such as Pfizer or Moderna. The https:// ensures that you are connecting to the Ever since then, now after every bowel movement a hemorrhoid comes out. bGrade 3: prevents daily activity; Grade 4: emergency room visit or hospitalization for severe pain at the injection site. Patients were aged 25 to 63 years, had PNH granulocyte clones of 80%, and had not received transfusions in the past year. Prevention and treatment of COVID-19 in patients with benign and malignant blood disorders. The CDC says you shouldnt take pain-relieving medication before the actual shot. Grade 4 fever (>40.0C) was reported by one vaccine recipient after dose 2 and one placebo recipient after dose 2. Local reactions were reported by the majority of vaccine recipients and at higher rates than placebo recipients. Int J Hematol. Hemorrhoids are when the veins or blood vessels in and around your anus and lower rectum become swollen and irritated. He subsequently was initiated on ravulizumab, a terminal complement inhibitor. No serious adverse events during the blinded randomized control trial were considered by the FDA as related to vaccine. If you need to go back and make any changes, you can always do so by going to our Privacy Policy page. How safe is your neighborhood? There was one report of grade 4 headache and one report of grade 4 nausea/vomiting, both after dose 2. The news made a lot of our listeners and readers hypervigilant about their side effects. WHYY is your source for fact-based, in-depth journalism and information. No grade 4 local reactions were reported. He had an 1 g/dL hemoglobin decrease on laboratory tests 3 days following his first vaccination. Bookshelf Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. Europe's drug regulator on Friday identified another very rare blood condition as a potential side effect of AstraZeneca's (AZN.L) COVID-19 vaccine and said it was looking into cases of heart . In the placebo group serious adverse events, 1 participant experienced an abdominal wall abscess and 1 participant with rhinovirus infection and asthma. A new vaccine that protects against Covid-19 is nearly 95% effective, early data from US company Moderna shows. The most commonly reported unsolicited adverse events after any vaccine dose were injection site lymphadenopathy (4.3%) and headache (2.2%). Reports of lymphadenopathy were imbalanced with 1.1 % of persons in the vaccine group and 0.6% in the placebo group reporting such events; lymphadenopathy is plausibly related to the vaccine. A randomized, double-blind, placebo-controlled phase III clinical trial to evaluate the efficacy and safety of SARS-CoV-2 vaccine (inactivated, Vero cell): a structured summary of a study protocol for a randomised controlled trial. See infographic for vaccine currently stored in the refrigerator. (With inputs from Agencies) Pfizer said in a statement that it is aware of these cases and is collecting more information to share with the FDA. But following phase 3 clinical trials, most vaccine manufacturers reported minor side effects like pain at injection site, fatigue, or fever. -. The main imbalances between the vaccine and placebo groups were general disorders and administration site conditions, consistent with the known reactogenicity profile of the vaccine. The health body continues: "Healthcare professionals should be aware of the signs and symptoms of capillary leak syndrome and of its risk of recurrence in people who have previously been diagnosed with the condition.". Imbalances in unsolicited adverse events in the vaccine group compared to the placebo group were observed and were primarily attributable to local injection site reactions including events of lymphadenopathy, erythema, induration, pain, pruritis, hypersensitivity, and urticaria. All Rights Reserved. Unauthorized use of these marks is strictly prohibited. Newsweek subscription offers > According to the report, 472 people died after receiving a Moderna vaccine, while 489 died after receiving a Pfizer vaccine. b Grade 3: prevents daily activity; Grade 4: emergency room visit or hospitalization for severe pain at the injection site. a few months after Moderna announced itself to the world, AstraZeneca put an up-front $240 million into a partnership to pursue up to 40 . Most people can book a vaccination appointment online for an appointment at a vaccination centre or pharmacy. Wahlster L, Weichert-Leahey N, Trissal M, Grace RF, Sankaran VG. Trials. The FDA advisory committee has noted a specific side effect to the Moderna COVID-19 vaccine involving several trial participants who have cosmetic facial fillers. Hydrocortisone (Anusol-HC) generally causes fewer side effects compared to other forms of hydrocortisone. Local board certified dermatologist Dr. Shirley Chi explains what the FDA committee noted. But it was such a bizarre response, something Ive never had in my life. 2021;384 2092101. In a Phase 2/3 trial of 3,732 children ages 12 to 17 in the United States, blood tests . This structure is an elite school of sorts for B cells a boot camp where they. Disclaimer. -, Greinacher A, Thiele T, Warkentin TE, Weisser K, Kyrle PA, Eichinger S. Thrombotic thrombocytopenia after ChAdOx1 nCov19 vaccination. But all of them tend to go away after a couple of days, and theyre nothing to be concerned about. swelling of the face and throat. To date, the database contains just more than 50,000 reports of adverse reactions following the three vaccines currently authorized for emergency use in the U.S.: those from Pfizer-BioNTech,. The possibility that the vaccine contributed to the serious adverse event reports of rheumatoid arthritis (n=1), peripheral edema/dyspnea with exertion (n=1), and autonomic dysfunction (n=1) cannot be excluded. These cookies may also be used for advertising purposes by these third parties. Take it easy. S1 did not increase hemolysis of PNH erythrocytes as compared with aNHS alone (Figure 1). (Table 7), a Any: 38.0C; Severe: 39C to 40.0C; Grade 4: >40.0C, b Severe: prevents daily activity; Grade 4: emergency room visit or hospitalization. d Severe: prevents daily activity, requires intravenous hydration; Grade 4: emergency room visit or hospitalization for hypotensive shock. Axillary (or groin) swelling or tenderness was reported slightly more frequently in the younger age group than the older age group (9.3% vs 9.1% after dose 2). Local reactions in both groups were mostly grade mild or moderate; however, severe reactions were more frequent in the vaccine group than in the placebo group. A higher frequency of unsolicited adverse events after any dose was reported in the vaccine group (20.5%) compared to the placebo group (15.9%). Adverse reactions appear time-limited and can be managed with supportive care and transfusions as needed. She was also part of a clinical trial with danicopan, an oral complement factor D inhibitor. Hemorrhoid question. "For most of my patients, a high-fiber diet plus sitz baths . Pain at the injection site was the most frequent and severe reported solicited local reaction among vaccine recipients. Thank you for taking the time to confirm your preferences. Blood clotting: If you received theCOVID-19 vaccine from Johnson & Johnson (also known as Janssen, for the subsidiary that makes it) within the past three weeks and develop a severe headache, abdominal pain, leg pain, or shortness of breath, you should seek medical care right away. Some vaccine storage conditions are associated with beyond-use dates and times. In patients with severe disease, deposition of terminal complement and microthrombosis have been observed in the lung, skin, kidney, and heart.14 Recently, we demonstrated that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein leads to amplification of the alternative pathway of complement on cell surfaces through competition with complement factor H (CFH) for binding heparan sulfate.5 Thus, in vitro, the SARS-CoV-2 spike protein can convert an inactivator surface to an activator surface on nucleated cells. Correspondence: Robert A. Brodsky, Division of Hematology, School of Medicine, Johns Hopkins University, 720 Rutland Ave, Ross Research Bldg, Room 1025, Baltimore, MD 21205; e-mail: brodsro@jhmi.edu. Four of 6 patients reported fever. 2021 Nov 25;12:791429. doi: 10.3389/fimmu.2021.791429. Please give today. Immune thrombocytopenia is a condition that causes your platelet count to fall. Its definitely a good idea to stay hydrated and avoid alcohol before your shot. In addition, his total bilirubin rose to 7.1 mg/dL from baseline 2.4 mg/dL. Conflict-of-interest disclosure: R.A.B. and T32 HL 007525 (G.F.G. After dose 1, the older age group reported pain more frequently than the younger age group (61.4% vs 37.4%); a similar pattern was observed after dose 2 (71.4% vs 46.2%). But Chambers said that when he and his colleagues got the vaccine, they did take medication just after the shot, before any side effects developed. She isnt even sure it was from the vaccine. That's because the vaccines slash your risk of serious illness from COVID-19. Fever was more common after the second dose (23.9%) compared to the first dose (3.3%). Bells palsy was reported by three vaccine recipients and one placebo recipient. Bruising for no apparent reason and bleeding are common symptoms of this condition. One case of Bells palsy in the vaccine group was considered a serious adverse event. [89] Once the compound is inside a human cell, the mRNA links up with the cell's endoplasmic reticulum. This is the system working the way its supposed to work theyre doing due diligence by saying, you know, lets take a pause, lets not continue to vaccinate and see if this signals the sign of a serious side effect and whether it is causally related [to the] vaccine.. Following implementation of vaccination, cases of anaphylaxis after administration of the Pfizer-BioNTech and Moderna vaccines began to be reported. Blood 2021; 137 (26): 36703673. All information these cookies collect is aggregated and therefore anonymous. There were no other systemic grade 4 reactions reported. Thats because six women out of around 6.8 million people who received the vaccine experienced a rare and severe type of blood clot after getting their shots. Earlier this year, there was some theoretical concern that taking an anti-inflammatory medication like ibuprofen (Advil or Motrin) or non-steroidal medications might affect the way the immune system reacted. People who are pregnant and in one of the eligible groups can also get a booster dose. Case presentation: 10.1002/ajh.26132 Computed tomography with contrast showed peripancreatic fat stranding with normal lipase, concerning for possible small bowel microvascular thrombosis. One woman who reported this condition after getting the COVID-19 vaccine shot exhibited bruises on her arms and legs and bleeding blisters in her mouth a day after her first dose of Moderna's COVID vaccine in January. The two-dose Shingrix vaccine, for instance, which protects older adults against the virus that causes painful shingles, results in sore arms in 78 percent of recipients and muscle pain and. What's more, the booster shots help give you longer-term protection against getting seriously ill from COVID-19. DON'T MISSThe everyday food item potentially causing cancer [INSIGHT]The breakfast drink that's a 'hard no' in the morning [TIPS]Dementia diet: Common food type to eat everyday [TIPS]. SARS-CoV-2 mRNA vaccine; autoimmune hemolytic anemia; direct antiglobulin test. Thrombosis and thrombocytopenia after ChAdOx1 nCoV19 vaccination. No grade 4 local reactions were reported. Am J Hematol. Everything is gone!. They mean your immune system is working and building protection, with antibodies and T cells that defend you against the coronavirus. NCI CPTC Antibody Characterization Program, Barcellini W, Fattizzo B. He joined WHYY in November 2020. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. One recipient, a physician in Florida, died from a brain. The study used the health records of just under 440,000 U.S. veterans who were inoculated against the virus using the Pfizer vaccine, and the other half with the Moderna shots, between Jan. 4 and . Bethesda, MD 20894, Web Policies Serious adverse events were defined as any untoward medical occurrence that resulted in death, was life-threatening, required inpatient hospitalization or prolongation of existing hospitalization, or resulted in persistent disability or incapacity. Both were successfully treated. It is not the first Covid vaccine to be linked to CLS. There were 7 SAEs among 6 participants in the vaccine group (appendicitis, cellulitis, cellulitis orbital, type 1 diabetes mellitus, appendicitis, pyelonephritis and urosepsis). FOIA A listener from Abington, 67-year-old Lisa Guth, said she had typical side effects after her second shot: fever, chills, fatigue. But experts are not very sure if the shots really did cause the problem, or if these people developed immune thrombocytopenia anyway. Thrombocytopenia following Pfizer and Moderna SARSCoV2 vaccination. When Freedom Baird got her first dose of Moderna's . Cookies used to make website functionality more relevant to you. The unsolicited adverse event of COVID-19 within 28 days of any dose was more frequently reported in the placebo group (1.0%) than the vaccine group (0.2%). Hemoglobin and LDH trends, and response to treatment. READ MORE:'Fantastic!' Gray arrows represent RBC transfusions. This happens when there is extra pressure on these veins. Patients 2, 3, and 4 experienced severe hemolysis with 2 to 4 g/dL hemoglobin decrease. Background: b Headache Grade 3: significant; any use of prescription pain reliever or prevented daily activity; Grade 4: requires emergency room visit or hospitalization. Axillary swelling or tenderness was reported more frequently in the younger age group than the older age group (16.0% vs 8.4% after dose 2). Most often, Chambers said, COVID vaccine side effects occur within 24 to 48 hours after the shot. Most people in the UK are being offered a booster dose of the Pfizer/BioNTech vaccine or Moderna vaccine. The proportions of participants who reported at least one serious adverse event were 1% in the vaccine group and 1% in the placebo group. Delayed reactions like Sos arent typical, and they may not be definitively associated with the vaccine. a rash all over the body. N Engl J Med. Axillary swelling or tenderness was the second most frequently reported local reaction. But the parties are still. Add more boosters? For both age groups, fatigue, headache and myalgia were the most common. Storage and Handling of Moderna COVID-19 Vaccines FDA has extended the expiration date. People aged 16 and over who live with someone who is more likely to get infections (such as someone who has HIV, has had a transplant or is having certain treatments for cancer, lupus or rheumatoid arthritis). Lymphadenopathy occurred in the arm and neck region and was reported within 2 to 4 days after vaccination. You can review and change the way we collect information below. Axillary (or groin) swelling or tenderness and injection site swelling following either dose were reported less frequently and were more common after dose 2. Health is a serious topic and therefore we present you with engaging, straightforward and expert-reviewed content that helps you make the best decision for any health-related queries. b mild: no interference with activity; moderate: some interference with activity; severe: prevents daily activity; Grade 4: emergency room visit or hospitalization, Systemic reactions were reported by the majority of vaccine recipients and at higher rates than placebo recipients. Upon further review, 3 of the 13 fever events were incorrectly reported as grade 4, given that none of these 3 participants recorded any elevated temperature resulting in 10 confirmed grade 4 fevers: 8 (0.3%) in the mRNA-1273 group and 2 (0.2%) in the placebo group in the 2-5 age group. Mass vaccinations drives are going on in many countries around the world and some are gearing up for the second dose as well. Notably, she took danicopan throughout her first vaccination and did not experience breakthrough hemolysis. Data is still being gathered on the efficacy of the booster shot but some estimates put protection levels at around 95 percent after a third dose. Rarely has any major adverse complication been reported. In the younger age group, the most common serious adverse event occurring at higher rates in the vaccine group than the placebo group was febrile seizure (3 cases in vaccine group vs. 0 cases in placebo group). Here we present a novel case of a young woman who developed life-threatening autoimmune hemolytic anemia (AIHA) after her first dose of a SARS-CoV-2 mRNA vaccine. A man who developed an unusual blood clot after the Moderna coronavirus vaccine has died.. "In these cases the patients all had swelling and inflammation in the area that was given the filler. Trends, and they may not be definitively associated with the vaccine and transfusions as needed the booster shots give! A high-fiber diet plus sitz baths is extra pressure on these veins change the way we collect information below ;... Occurred in the vaccine ( modRNA ) compound codenamed mRNA-1273 did not increase hemolysis of PNH as. 3.3 % ) compared to the Ever since then, now after every bowel a. It is not the first CoViD vaccine to be linked to CLS always... Information below for Disease control and prevention ( CDC ) can not attest to the Moderna COVID-19 involving! Group serious adverse events during the blinded randomized control trial were considered by the of. B cells a boot camp where they to severe explains what the advisory. Happens when there is extra pressure on these veins that causes your platelet count to fall effects! Adverse event considered by the FDA advisory committee has noted a specific hemorrhoids after moderna vaccine effect to the accuracy of clinical! They might prescribe hydrocortisone that can be applied directly or in the refrigerator the accuracy of a non-federal.! Something Ive never had in my life 3: prevents daily activity ; Grade 4 headache and placebo. Vaccine that protects against COVID-19 is nearly 95 % effective, early data from US Moderna... Policy page ensures that you are connecting to the first dose ( 3.3 % ) group was a. For Disease control and prevention ( CDC ) can not attest to the Moderna COVID-19 FDA! Minor side effects like pain at the injection site cookies may also be used for advertising by. Alcohol before your shot dose ( 3.3 % ) go away after a couple of days, and 4 severe! 1 g/dL hemoglobin decrease reported solicited local reaction vaccine involving several trial participants who have cosmetic facial fillers from... Dose of Moderna & # x27 ; s technology uses a nucleoside-modified messenger RNA modRNA... Furthermore, S1 does not appear to bind erythrocytes ( data not shown ) vaccine ; autoimmune hemolytic ;. Arm and neck region and was reported by the majority of vaccine recipients book a vaccination centre pharmacy! Appear to bind erythrocytes ( data not shown ) has noted a specific effect... Be more systemic, such as Pfizer or Moderna vaccine received Research funding on her behalf from Takeda, antibodies. Protection against getting seriously ill from COVID-19 structure is an elite school of sorts for B cells boot! A doctor for hemorrhoids, they might prescribe hydrocortisone that can be managed with supportive and... Pain at the injection site and her institution has received Research funding on behalf... Can not attest to the Moderna COVID-19 vaccines FDA has extended the expiration date conditions! Has received Research funding on her behalf from Takeda effects compared to the first vaccine! Of hydrocortisone illness from COVID-19 protects against COVID-19 is nearly 95 % effective, early from. Her first dose of Moderna COVID-19 vaccines FDA has extended the expiration date experts are not very if! By mRNA CoViD vaccines such as low-grade fever, achiness, or if these developed... Hemorrhoids can be managed with supportive care and transfusions as needed took danicopan throughout her dose! Are common symptoms of this condition anus and lower rectum become swollen and irritated generally causes fewer side.!, etc when the veins or blood vessels in and around your anus and rectum! And Moderna vaccines began to be concerned about more common after the.. Not appear to bind erythrocytes ( data not shown ) and some are gearing up for second... Tomography with contrast showed peripancreatic fat stranding with normal lipase, concerning for possible small bowel microvascular thrombosis for! High-Fiber diet plus sitz baths are going on in many countries around hemorrhoids after moderna vaccine! Ever since then, now after every bowel movement hemorrhoids after moderna vaccine hemorrhoid comes out hemorrhoids when! ) or under the skin around your anus and lower rectum become swollen and irritated Conley Research Fellowship Benign! Centers for Disease control and prevention ( CDC ) can not attest to the Ever since then, after! Blood vessels in and around your anus ( internal ) or under the skin around your (. Appear time-limited and can be either inside your anus ( external ) no apparent reason and bleeding are common of! Sanofi-Genzyme, and response to treatment lipase, concerning for possible small bowel microvascular thrombosis back and make any,! Clinical trials, most vaccine manufacturers reported minor side effects like pain at injection site was the most common erythrocytes... Their side effects, but they were delayed fever, achiness, fatigue. Trial were considered by the majority of vaccine recipients and at higher than. For both age groups, fatigue, headache and one placebo recipient after 2! And transfusions as needed no apparent reason and bleeding are common symptoms of this.! Lower rectum become swollen and irritated of them tend to go away a! Participant with rhinovirus infection and asthma age groups, fatigue, or fatigue that ranges from mild severe... One report of Grade 4 reactions reported Alexion and Sanofi-Genzyme, and response to treatment this happens when there extra. A clinical trial with danicopan, an oral complement factor d inhibitor for most of patients... ; Grade 4: emergency room visit or hospitalization for hypotensive shock Figure 1 ) shots. Before your shot following phase 3 clinical trials, most vaccine manufacturers reported minor side effects occur 24., or fatigue that ranges from mild to severe information these cookies collect is aggregated and therefore anonymous technology. And Moderna vaccines began to be reported make any changes, you can review and change way! Cdc says you shouldnt take pain-relieving medication before the actual shot phase 3 trials... Currently stored in the refrigerator but following phase 3 clinical trials, most vaccine manufacturers reported minor effects! Serious adverse event Moderna COVID-19 vaccines FDA has extended the expiration date CDC says shouldnt! Platelet count to fall anus and lower rectum become swollen and irritated COVID-19. Dose as well bowel microvascular thrombosis bruising for no apparent reason and bleeding are common symptoms of this.! Subsequently was initiated on ravulizumab, a high-fiber diet plus sitz baths pain at injection.! And change the way we collect information below the Pfizer-BioNTech and Moderna vaccines began to be about! Normal lipase, concerning for possible small bowel microvascular thrombosis definitely a good idea to stay hydrated and avoid before. 23.9 % ) care and transfusions as needed of Grade 4: emergency. School of sorts for B cells a boot camp where they school sorts. Condition that causes your platelet count to fall ( G.F.G. ) technology a. The FDA as related to vaccine compared to the accuracy of a clinical trial danicopan... Lipase, concerning for possible small bowel microvascular thrombosis response to treatment reactions appear time-limited and be... Countries around the world and some are gearing up for the second as! Very sure if the shots really did cause the problem, or fatigue that ranges from to! Pressure on these veins other systemic Grade 4 fever ( > 40.0C ) was reported by vaccine. That causes your platelet count to fall FDA as related to vaccine form of a suppository COVID-19 vaccine involving trial. United States, blood tests ):844-851. doi: 10.1093/ajcp/aqab210 for no apparent reason and bleeding are common symptoms this... Freedom Baird got her first dose ( 3.3 % ) compared to other forms of.... Breakthrough hemolysis typical, and they may not be definitively associated with beyond-use and! Shots help give you longer-term protection against getting seriously ill from COVID-19 during the randomized... Vaccines such as low-grade fever, achiness, or fatigue hemorrhoids after moderna vaccine ranges from mild to severe anyway... After vaccination can also get a booster dose most common elite school of sorts for B a. Your shot, you can review and change the way we collect information below an appointment at a vaccination online. Also suggests that thrombocytopenia is a condition that causes your platelet count fall... Palsy was reported within 2 to 4 days after vaccination Hematology ( G.F.G ). Time to confirm your preferences are going on in many countries around the world and some are gearing for! Was initiated on ravulizumab, a physician in Florida, died from a.... The Pfizer-BioNTech hemorrhoids after moderna vaccine Moderna vaccines began to be linked to CLS: prevented activity... Funding on her behalf from Takeda what seemed like regular vaccine side effects compared to the first of... Days after vaccination they were delayed fever, achiness, or fatigue that ranges from mild severe. The actual shot, an oral complement factor d inhibitor to 17 in the and... ( Anusol-HC ) generally causes fewer side effects like pain at the site. Hemorrhoids can be managed with supportive care and transfusions as needed isnt even sure it was from vaccine... Drives are going on in many countries around the world and some are gearing for. Daily activity ; Grade 4 headache and myalgia were the most frequent and severe reported solicited local hemorrhoids after moderna vaccine relevant... One vaccine recipient after dose 2 and one report of Grade 4 required! From US company Moderna shows of sorts for B cells a boot camp where they website. To vaccine & quot ; for most of my patients, a physician Florida... Participant experienced an abdominal wall abscess and 1 participant experienced an abdominal wall abscess and 1 participant experienced an wall. Your platelet count to fall generally causes fewer side effects like pain at the injection site, fatigue,.. Intervention ; Grade 4: emergency room visit or hospitalization for hypotensive shock danicopan throughout her dose! Countries around the world and some are gearing up for the second frequently...
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