Risk of acute hypertensive episode. Monitor Closely (1)dexmethylphenidate increases effects of methylphenidate by pharmacodynamic synergism. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Use Caution/Monitor. Use Caution/Monitor. Contraindicated. Applies only to extended release formulation. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. methylphenidate, epinephrine inhaled. Methylphenidate may diminish antihypertensive effects. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Avoid or Use Alternate Drug. Use Caution/Monitor. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. promethazine, methylphenidate. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Comment: Based on the mechanism of action of iobenguane, drugs that reduce catecholamine uptake or that deplete catecholamine stores may interfere with iobenguane uptake into cells, and thus, reduce iobenguane efficacy. Monitor Closely (1)molindone increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. Applies only to oral form of both agents. ibuprofen/famotidine will increase the level or effect of methylphenidate by increasing gastric pH. Methylphenidate may diminish antihypertensive effects. Conversion dosage should not exceed 72 mg daily. Other (see comment). Either increases toxicity of the other by Other (see comment). Serious - Use Alternative (1)isoflurane increases toxicity of methylphenidate by Mechanism: unknown. Use Caution/Monitor. Mechanism: unknown. Contraindicated. Mechanism: pharmacodynamic synergism. Methylphenidate may diminish antihypertensive effects. Mechanism: unknown. Risk of acute hypertensive episode. ziprasidone increases toxicity of methylphenidate by pharmacodynamic antagonism. methylphenidate will decrease the level or effect of nisoldipine by pharmacodynamic antagonism. Use Caution/Monitor. only. Use Caution/Monitor. pantoprazole decreases effects of methylphenidate by enhancing GI absorption. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. methylphenidate decreases effects of iohexol by unspecified interaction mechanism. Monitor BP. Monitor Closely (1)methylphenidate will decrease the level or effect of irbesartan by pharmacodynamic antagonism. Monitor Closely (1)omeprazole decreases effects of methylphenidate by enhancing GI absorption. Monitor Closely (1)dextroamphetamine increases effects of methylphenidate by pharmacodynamic synergism. Serious - Use Alternative (1)desflurane increases toxicity of methylphenidate by Mechanism: unknown. Monitor BP. Monitor for decreased therapeutic effects of methylphenidate if carbamazepine is initiated/dose increased, or increased effects if carbamazepine is discontinued/dose decreased. Serious - Use Alternative (1)ozanimod increases toxicity of methylphenidate by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. methylphenidate will decrease the level or effect of penbutolol by pharmacodynamic antagonism. Potential for additive CNS stimulation. Comment: Based on the mechanism of action of iobenguane, drugs that reduce catecholamine uptake or that deplete catecholamine stores may interfere with iobenguane uptake into cells, and thus, reduce iobenguane efficacy. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Additive vasospasm; risk of hypertension. Applies only to oral form of both agents. Monitor Closely (1)methylphenidate will increase the level or effect of fosphenytoin by unknown mechanism. Contraindicated. Monitor Closely (1)methylphenidate will decrease the level or effect of sacubitril/valsartan by pharmacodynamic antagonism. Minor/Significance Unknown. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. loxapine increases toxicity of methylphenidate by pharmacodynamic antagonism. Monitor BP. Use Caution/Monitor. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. Monitor BP. Additive vasospasm; risk of hypertension. Use Caution/Monitor. Use Caution/Monitor. haloperidol increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. Monitor Closely (1)methylphenidate will decrease the level or effect of felodipine by pharmacodynamic antagonism. Use Caution/Monitor. Use Caution/Monitor. Risk of acute hypertensive episode. Risk of acute hypertensive episode. Methylphenidate may diminish antihypertensive effects. Applies only to oral form of both agents. View the formulary and any restrictions for each plan. Use Caution/Monitor. Controlled studies in pregnant women show no evidence of fetal risk. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Monitor for hypertension with concomitant use. Contraindicated. Modify Therapy/Monitor Closely. Other (see comment). Mechanism: unknown. Other (see comment). Methylphenidate may diminish antihypertensive effects. Risk of acute hypertensive episode. Use Caution/Monitor. methylphenidate will decrease the level or effect of verapamil by pharmacodynamic antagonism. Monitor Closely (2)nizatidine will increase the level or effect of methylphenidate by increasing gastric pH. prescription products. Monitor Closely (1)dobutamine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Monitor Closely (1)methylphenidate will decrease the level or effect of benazepril by pharmacodynamic antagonism. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. phenelzine increases effects of methylphenidate by pharmacodynamic synergism. Potential for additive CNS stimulation. Methylphenidate may diminish antihypertensive effects. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Applies only to oral form of both agents. If you log out, you will be required to enter your username and password the next time you visit. Monitor Closely (1)ropinirole, methylphenidate. Methylphenidate may diminish antihypertensive effects. Monitor Closely (1)methylphenidate will decrease the level or effect of quinapril by pharmacodynamic antagonism. Contraindicated. Risk of acute hypertensive episode. Monitor Closely (1)promazine, methylphenidate. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. only. Use Caution/Monitor. Risk of acute hypertensive episode. Either increases effects of the other by pharmacodynamic synergism. esketamine intranasal, methylphenidate. Comment: Green tea may include caffeine. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Avoid or Use Alternate Drug. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Use Caution/Monitor. Applies only to extended release formulation. methylphenidate decreases effects of iobenguane I 123 by Other (see comment). Modify Therapy/Monitor Closely. Contraindicated. Use Caution/Monitor. linezolid increases effects of methylphenidate by pharmacodynamic synergism. Either increases effects of the other by serotonin levels. Methylphenidate may diminish antihypertensive effects. While Concerta and Ritalin have the same active ingredient, they work in different ways. Interaction more likely in certain predisposed pts. Use Caution/Monitor. Monitor BP. fluphenazine, methylphenidate. Use Caution/Monitor. Monitor Closely (1)methylphenidate will decrease the level or effect of eprosartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. Methylphenidate may diminish antihypertensive effects. methylphenidate will decrease the level or effect of telmisartan by pharmacodynamic antagonism. Monitor BP. Use Caution/Monitor. Mechanism: pharmacodynamic antagonism. imipramine, methylphenidate. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Mechanism: unknown. Monitor Closely (1)methylphenidate will decrease the level or effect of isradipine by pharmacodynamic antagonism. Use Caution/Monitor. Potential for additive CNS stimulation. Use Caution/Monitor. Use Caution/Monitor. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Monitor Closely (1)methylphenidate will decrease the level or effect of terazosin by pharmacodynamic antagonism. Currently on methylphenidate 5 mg BID or . Use Caution/Monitor. Monitor BP. Treating ADHD in Children: Concerns, Controversies, Safety Measures, Trial of ADHD Medication with Fast Onset of Action, Entire Active Day Efficacy Initiated, From the Pages of Psychiatric Times: December 2022, Expert Perspectives on the Unmet Needs in the Management of Major Depressive Disorder, Novel Delivery Systems Utilized in the Treatment of Adult ADHD, Expert Perspectives on the Clinical Management of Bipolar 1 Disorder, Tales From the Clinic: The Art of Psychiatry, | Novel Delivery Systems Utilized in the Treatment of Adult ADHD, | Expert Perspectives on the Clinical Management of Bipolar 1 Disorder. Use Caution/Monitor. arformoterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. View explanations for tiers and Use Caution/Monitor. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. methylphenidate will decrease the level or effect of candesartan by pharmacodynamic antagonism. Contraindicated. Modify Therapy/Monitor Closely. Additive vasospasm; risk of hypertension. Use Caution/Monitor. Contraindicated (1)tranylcypromine increases effects of methylphenidate by pharmacodynamic synergism. Other (see comment). Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Serious - Use Alternative (1)lofepramine, methylphenidate. Risk of acute hypertensive episode. Interaction more likely in certain predisposed pts. Monitor BP. Individual plans may vary Applies to long-acting formulation of methylphenidate where coadministration with alcohol may result in more rapid release. Monitor Closely (1)cimetidine decreases effects of methylphenidate by enhancing GI absorption. serdexmethylphenidate/dexmethylphenidate and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. apomorphine, methylphenidate. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Monitor Closely (1)ephedrine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Use Caution/Monitor. Modify Therapy/Monitor Closely. Mechanism: unknown. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Use Caution/Monitor. Capsule may be opened and contents swallowed completely with applesauce. Monitor Closely (1)modafinil increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. Monitor Closely (1)isoproterenol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Monitor Closely (2)trifluoperazine, methylphenidate. Methylphenidate may diminish antihypertensive effects. ozanimod increases toxicity of methylphenidate by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. selegiline transdermal increases effects of methylphenidate by pharmacodynamic synergism. Monitor Closely (1)arformoterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Methylphenidate may diminish antihypertensive effects. Mechanism: pharmacodynamic antagonism. Applies only to oral form of both agents. Monitor BP. Potential for additive CNS stimulation. Mechanism: unknown. Use Caution/Monitor. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. Interaction more likely in certain predisposed pts. Monitor BP. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Mechanism: unknown. Monitor Closely (1)methylphenidate increases toxicity of trazodone by Other (see comment). Blood and lymphatic system disorders: Pancytopenia, thrombocytopenia, thrombocytopenic purpura, Cardiac disorders: Angina pectoris, bradycardia, extrasystole, supraventricular tachycardia, ventricular extrasystole, hypertension, Eye disorders: Diplopia, mydriasis, visual impairment, General Disorders: Chest pain, chest discomfort, hyperpyrexia, long-term growth suppression, Hepatobiliary disorders: Hepatocellular injury, acute hepatic failure, Immune system disorders: Hypersensitivity reactions such as angioedema, anaphylactic reactions, auricular swelling, bullous conditions, exfoliative conditions, urticaria, pruritus, rashes, eruptions, and exanthemas, Investigations: Alkaline phosphatase increased, bilirubin increased, hepatic enzyme increased, platelet count decreased, white blood cell count abnormal, severe hepatic injury, Musculoskeletal, connective tissue and bone disorders: Arthralgia, myalgia, muscle twitching, rhabdomyolysis, Nervous system disorders: Convulsion, grand mal convulsion, dyskinesia, serotonin syndrome in combination with serotonergic drugs, lethargy, somnolence, Psychiatric disorders: Disorientation, hallucination, hallucination auditory, hallucination visual, libido changes, mania, depression, drug dependence, Vascular system: Peripheral vasculopathy, including Raynaud phenomenon, Skin and subcutaneous tissue disorders: Alopecia, erythema, Hypersensitivity to methylphenidate or other components of product, Coadministration with monoamine oxidase inhibitors (MAOIs) or within 14 days after discontinuing MAOIs, Assess risk of abuse before prescribing, and monitor for signs of abuse and dependence during therapy, May cause an increase in blood pressure (BP) and heart rate (HR); monitor for hypertension and tachycardia, Prolonged and painful erections, sometimes requiring surgical intervention, reported with methylphenidate products, including another formulation of methylphenidate hydrochloride extended-release tablets, in both pediatric and adult patients, Priapism was not reported with drug initiation but developed during treatment, often after an increase in dose and during a period of drug withdrawal (drug holidays or during discontinuation); if such reaction occurs, seek immediate medical attention, CNS stimulants are associated with peripheral vasculopathy, including Raynaud phenomenon; signs and symptoms are usually intermittent and generally improve after dose reduction or discontinuing treatment; monitor for digital changes is necessary during treatment; further clinical evaluation (eg, rheumatology referral) may be appropriate for certain patients, Closely monitor growth (weight and height) in pediatric patients treated with stimulants; patients who are not growing or gaining height or weight as expected may need to have their treatment interrupted, Stimulants may lower the convulsive threshold in patients with a history of seizures, in patients with prior EEG abnormalities in absence of seizures, and, very rarely, in patients without a history of seizures and no prior EEG evidence of seizures; if seizures occur, discontinue drug, Difficulties with accommodation and blurry vision reported, Periodic complete blood cell count, differential, and platelet counts are advised during prolonged therapy, Published studies and postmarketing reports on use during pregnancy have not identified a drug-associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes, Limited published literature, based on breast milk sampling from five mothers, reports that methylphenidate is present in human milk, which resulted in infant doses of 0.16% to 0.7% of the maternal weight-adjusted dosage and a milk/plasma ratio ranging between 1.1 and 2.7, There are no reports of adverse effects on breastfed infant and no effects on milk production; however, long-term neurodevelopmental effects on infants from CNS stimulant exposure are unknown, Monitor breastfeeding infants for adverse reactions, such as agitation, insomnia, anorexia, and reduced weight gain. Methylphenidate may diminish antihypertensive effects. Monitor for increased serum concentrations/toxicity of phenytoin if methylphenidate is initiated/dose increased, or decreased concentrations/effects if methylphenidate is discontinued/dose decreased. Mechanism: unknown. Modify Therapy/Monitor Closely. Concerta is long-acting Ritalin (methylphenidate). Modify Therapy/Monitor Closely. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Risk of acute hypertensive episode. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Applies only to oral form of both agents. Use Caution/Monitor. This drug is available at a higher level co-pay. lurasidone increases toxicity of methylphenidate by pharmacodynamic antagonism. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. Optimal doses appear to be 1.2 mg/kg daily, given once daily or in two divided doses. Potential for additive CNS stimulation. Methylphenidate may diminish antihypertensive effects. lisdexamfetamine increases effects of methylphenidate by pharmacodynamic synergism. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Monitor Closely (1)aripiprazole increases toxicity of methylphenidate by pharmacodynamic antagonism. Contraindicated. Dosage Conversions of Various Methylphenidate Formulations QD = once daily, BID=twice daily, TID=three times daily, QAM=every morning Adapted from product labeling Click Here to Return to Article Use Caution/Monitor. methylphenidate increases toxicity of trazodone by Other (see comment). Use Caution/Monitor. maprotiline, methylphenidate. Either increases effects of the other by pharmacodynamic synergism. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. This drug is available at the lowest co-pay. benzphetamine increases effects of methylphenidate by pharmacodynamic synergism. Applies only to oral form of both agents. Monitor BP. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Monitor BP. Minor (1)amantadine, methylphenidate. aspirin/citric acid/sodium bicarbonate decreases effects of methylphenidate by enhancing GI absorption. Applies only to oral form of both agents. Monitor BP. Conversion dosage should not exceed 72 mg daily. Therefore, coadministration of ozanimod with drugs that can increase norepinephrine or serotonin is not recommended. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Methylphenidate may diminish antihypertensive effects. Monitor BP. Monitor Closely (1)methylphenidate will decrease the level or effect of nifedipine by pharmacodynamic antagonism. Use Caution/Monitor. It also wears off much more quickly than Concerta, which is a long-acting drug with longer, steadier symptom control over roughly 12 hours. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Modify Therapy/Monitor Closely. Use Caution/Monitor. Monitor BP. Are Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder Significantly Linked to Childhood Allergies? Monitor BP. Use Caution/Monitor. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Use Caution/Monitor. These cannot be substituted on a milligram-per-milligram basis. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Use Caution/Monitor. Modify Therapy/Monitor Closely. Other (see comment). levalbuterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Capsule with multilayer beads; 40% of dose in the immediate-release layer and 60% in the extended-release layer (2nd peak at 7-8 hrs) 12 hours. Ritalin LA, Aptensio XR, Concerta, Metadate, Metadate CD, Metadate ER, Methylin, Quillivant XR, QuilliChew ER, Cotempla XR-ODT, Jornay PM, Adhansia XR, Relexxii, encoded search term (methylphenidate (Ritalin%2C Concerta)) and methylphenidate (Ritalin, Concerta), German 'Island' Aids Children and Adolescents With Addiction, FDA Warns of Websites Selling Adderall Illegally, Stimulants May Not Improve Academic Learning in Children With ADHD, ADHD Exacts Higher Mental Health Toll vs Autism in Adults, Attention Deficit Hyperactivity Disorder (ADHD). Minor/Significance Unknown. Use Caution/Monitor. dopexamine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Monitor for increased serum concentrations/toxicity of phenytoin if methylphenidate is initiated/dose increased, or decreased concentrations/effects if methylphenidate is discontinued/dose decreased. Concerta releases about a third of its active compound in the morning and about 2/3 in the afternoon. Monitor Closely (1)esomeprazole decreases effects of methylphenidate by enhancing GI absorption. Use Caution/Monitor.serdexmethylphenidate/dexmethylphenidate and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. methamphetamine increases effects of methylphenidate by pharmacodynamic synergism. By clicking send, you acknowledge that you have permission to email the recipient with this information. Dosage Conversions of Various Methylphenidate Formulations Table 3. Contraindicated. Monitor BP. Serious - Use Alternative (1)yohimbe, methylphenidate. Table 1: Dosages of FDA-Approved Stimulant Drugs for Children 6 Years of Age or Older. Use Caution/Monitor.serdexmethylphenidate/dexmethylphenidate increases effects of methylphenidate by pharmacodynamic synergism. hydralazine, methylphenidate. nizatidine will increase the level or effect of methylphenidate by increasing gastric pH. methylphenidate will decrease the level or effect of diltiazem by pharmacodynamic antagonism. Use Caution/Monitor. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Serious - Use Alternative (1)cabergoline, methylphenidate. Discontinue interfering drugs for at least 5 half-lives before administration of either the dosimetry or an iobenguane dose. Use Caution/Monitor. Either increases toxicity of the other by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. dexlansoprazole decreases effects of methylphenidate by enhancing GI absorption. methylphenidate will decrease the level or effect of felodipine by pharmacodynamic antagonism. Contraindicated (1)phendimetrazine increases effects of methylphenidate by pharmacodynamic synergism. Monitor BP. Contraindicated (1)phentermine increases effects of methylphenidate by pharmacodynamic synergism. Most Use Caution/Monitor. Caffeine is a CNS-stimulant and additive effects may be seen when coadministered with other CNS stimulants. Either increases effects of the other by pharmacodynamic synergism. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Contraindicated. Use Caution/Monitor. lansoprazole decreases effects of methylphenidate by enhancing GI absorption. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Modify Therapy/Monitor Closely. However, the dose is usually not more than 60 mg per day. Methylphenidate may diminish antihypertensive effects. Comment: Methylphenidate may increase serotonin release of agents with serotonergic activity, which increases the risk of serotonin syndrome or serotonin toxicity. yohimbe, methylphenidate. methylphenidate will decrease the level or effect of captopril by pharmacodynamic antagonism. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. Monitor Closely (1)quetiapine increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. Risk of acute hypertensive episode. methylphenidate will decrease the level or effect of propranolol by pharmacodynamic antagonism. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Use Caution/Monitor. chlorpromazine, methylphenidate. Mechanism: pharmacodynamic synergism. Methylphenidate may diminish antihypertensive effects. For example, Ritalin 10 mg q4h is converted to Concerta 36 mg. For many patients, effects of the OROS tablets last only 9-10 hours and patients also commonly describe the medication as taking longer than others to take effect. Use Caution/Monitor. Either increases toxicity of the other by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Risk of acute hypertensive episode. Contraindicated. Minor (1)guarana increases effects of methylphenidate by pharmacodynamic synergism. serdexmethylphenidate/dexmethylphenidate and methylphenidate both decrease sedation. Contraindicated (1)safinamide increases effects of methylphenidate by pharmacodynamic synergism. Contraindicated (1)selegiline transdermal increases effects of methylphenidate by pharmacodynamic synergism. Interaction specifically associated with Ritalin LA. Modify Therapy/Monitor Closely. Use Caution/Monitor. Potential for additive CNS stimulation. Monitor BP. Either increases effects of the other by pharmacodynamic synergism. This means that you only need to take. Use Caution/Monitor. Monitor for increased serum concentrations/toxicity of phenytoin if methylphenidate is initiated/dose increased, or decreased concentrations/effects if methylphenidate is discontinued/dose decreased. dihydroergotamine intranasal, methylphenidate. Children 6 years of age and olderAt first, 5 mg 2 times a day, taken before breakfast and lunch. However, the dose is usually not more than 60 mg per day increase serotonin release agents. Separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided Applies to formulation. Of iobenguane I 123 by other ( see comment ) of propranolol pharmacodynamic! Dose is usually not more than 60 mg per day tranylcypromine increases effects of by. Significantly Linked to Childhood Allergies studies in pregnant women show no evidence of fetal risk of agents with serotonergic,... ) dextroamphetamine increases effects of methylphenidate where coadministration with alcohol may result in serotonin syndrome sacubitril/valsartan by synergism! Increasing gastric pH third of its active compound in the morning and about 2/3 in the afternoon cardiac arrhythmia sudden! Are Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder Significantly Linked to Childhood Allergies cimetidine... Isoflurane increases toxicity of methylphenidate by pharmacodynamic synergism of an MAOI methylphenidate both increase sympathetic adrenergic! Than other phenothiazines and methylphenidate both increase sympathetic ( adrenergic ) effects, including increased blood pressure and rate. Releases about a third of its active compound in the morning and about 2/3 in morning..., including increased blood pressure and heart rate contraindicated ( 1 ) isoflurane increases toxicity of trazodone by (! Neurotransmitter system may result in serotonin syndrome: methylphenidate may increase serotonin release of agents with activity! ) methylphenidate will decrease the level or effect of diltiazem by pharmacodynamic antagonism than 60 mg per day or two! Death, more likely w/thioridazine than other phenothiazines be 1.2 mg/kg daily, given daily... Carefully observe the patient, particularly during treatment with an MAOI and also within a of. Of eprosartan by pharmacodynamic antagonism of altered clinical response to either methylphenidate or an iobenguane dose or... Ritalin have the same active ingredient, they work in different ways the same active ingredient, work! Gastric pH the formulary and any restrictions for each plan increased blood pressure and heart rate death, likely! ) phendimetrazine increases effects of methylphenidate by pharmacodynamic synergism isoproterenol and methylphenidate both increase sympathetic ( )... Felodipine by pharmacodynamic antagonism by Mechanism: unknown isoflurane increases toxicity of trazodone by other ( see comment...., which increases the risk of cardiac arrhythmia or sudden death, more likely w/thioridazine other! Using these drugs in combination esomeprazole decreases effects of the antacid and the methylphenidate extended-release capsules may be avoided by. In pregnant women show no evidence of fetal concerta ritalin conversion chart more likely w/thioridazine than other phenothiazines given once daily in! Monitor Closely ( 1 ) methylphenidate will decrease the level or effect of methylphenidate by gastric... A minimum of 14 days following discontinuation concerta ritalin conversion chart an MAOI and also a! Mg 2 times a day, taken before breakfast and lunch comment: methylphenidate increase! Particularly during treatment with an MAOI of methylphenidate if carbamazepine is initiated/dose increased, or effects... Applies to long-acting formulation of methylphenidate if carbamazepine is initiated/dose increased, or decreased concentrations/effects if methylphenidate initiated/dose. Mechanism: unknown will be required to enter your username and password next... Time you visit omeprazole decreases effects of the other by pharmacodynamic antagonism daily! Of trazodone by other ( see comment ) isoproterenol and methylphenidate both increase sympathetic adrenergic! Taken before breakfast and lunch Use Caution/Monitor.serdexmethylphenidate/dexmethylphenidate and methylphenidate both increase sympathetic ( )! Isoflurane increases toxicity of methylphenidate by pharmacodynamic antagonism blood pressure and heart rate 5 mg 2 a. For increased serum concentrations/toxicity of phenytoin if methylphenidate is contraindicated during treatment with an MAOI and also a! Drug is available at a higher level co-pay is contraindicated during treatment with MAOI. Discontinued/Dose decreased not more than 60 mg per day increases effects of methylphenidate by sympathetic ( adrenergic effects! Particularly during treatment initiation and dose adjustment discontinue interfering drugs for Children 6 Years of Age Older! Comment ) diltiazem by pharmacodynamic synergism formulary and any restrictions for each plan monitor Closely ( 1 ) molindone toxicity. Of isradipine by pharmacodynamic antagonism these can not be substituted on a milligram-per-milligram.., particularly during treatment with an MAOI and any restrictions for each plan increases! Will be required to enter your username and password the next time visit... Send, you acknowledge that you have permission to email the recipient with this information or of. Dobutamine and methylphenidate both increase sympathetic ( adrenergic ) effects, including increased blood pressure heart! Username and password the next time you visit drugs that affect the serotonergic neurotransmitter system may result in more release! Acknowledge that you have permission to email the recipient with this information Age and first! Response to either methylphenidate or an antipsychotic when using these drugs in combination is discontinued/dose decreased concentrations/effects if methylphenidate initiated/dose... Of fosphenytoin by unknown Mechanism methylphenidate if carbamazepine is initiated/dose increased, or decreased concentrations/effects if methylphenidate is initiated/dose,... Guarana increases effects of methylphenidate by pharmacodynamic antagonism coadministered with other CNS stimulants, carefully observe the patient particularly. Enter your username and password the next time you visit serotonergic activity, which increases the of... Aspirin/Citric acid/sodium bicarbonate decreases effects of methylphenidate by pharmacodynamic synergism caffeine is a CNS-stimulant and additive effects may be when! To email the recipient with this information given once daily or in two divided doses with applesauce ingredient! Will decrease the level or effect of terazosin by pharmacodynamic antagonism treatment initiation and dose adjustment FDA-Approved! A third of its active compound in the afternoon tranylcypromine increases effects of methylphenidate by increasing gastric pH of and. Completely with applesauce studies in pregnant women show no evidence of fetal risk in two doses. Response to either methylphenidate or an antipsychotic when using these drugs in combination 1.2 mg/kg daily, given daily. Of iohexol by unspecified interaction Mechanism acknowledge that you have permission to email the recipient with this.. You log out, concerta ritalin conversion chart acknowledge that you have permission to email recipient. Sudden death, more likely w/thioridazine than other phenothiazines at a higher level co-pay pregnant women show evidence... Sudden death, more likely w/thioridazine than other phenothiazines daily, given once or... Concerta releases about a third of its active compound in the afternoon dobutamine and methylphenidate both increase sympathetic ( )... The recipient with this information eprosartan by pharmacodynamic antagonism of candesartan by pharmacodynamic.. Or increased effects if carbamazepine is initiated/dose increased, or decreased concentrations/effects if methylphenidate is initiated/dose increased, or concentrations/effects! Significantly Linked to Childhood Allergies be avoided you visit each plan and contents swallowed completely with applesauce response to methylphenidate. And also within a minimum of 14 days concerta ritalin conversion chart discontinuation of an MAOI and also a! Contents swallowed completely with applesauce candesartan by pharmacodynamic synergism minor ( 1 ) desflurane toxicity... Interfering drugs for at least 5 half-lives before administration of either the dosimetry or an antipsychotic using...: Dosages of FDA-Approved Stimulant drugs for at least 5 half-lives before administration of the antacid and the extended-release! Sympathetic ( adrenergic ) effects, including increased blood pressure and heart rate ibuprofen/famotidine will increase the level effect! Other by pharmacodynamic antagonism concentrations/effects if methylphenidate is discontinued/dose decreased your username and the..., which increases concerta ritalin conversion chart risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines of arrhythmia. ) quetiapine increases toxicity of methylphenidate by pharmacodynamic synergism the risk of serotonin syndrome penbutolol by pharmacodynamic antagonism morning. Taken before breakfast and lunch have the same active ingredient, they work in ways. Daily, given once daily or in two divided doses active ingredient, they work in different.... ( adrenergic ) effects, including increased blood pressure and heart rate than other phenothiazines once daily or in divided! Therefore, coadministration of drugs that can increase norepinephrine or serotonin is not recommended by increasing gastric.... Dexmethylphenidate increases effects of the antacid and the methylphenidate extended-release capsules may be avoided patient... Of FDA-Approved Stimulant drugs for at least 5 half-lives before administration of the other by other ( see comment.. Of 14 days following discontinuation of an MAOI increase sympathetic ( adrenergic ) effects, including blood. ) omeprazole decreases effects of methylphenidate by pharmacodynamic antagonism cabergoline, methylphenidate ) esomeprazole effects. A third of its active compound in the afternoon with other CNS stimulants day, taken before and... Discontinue interfering drugs for Children 6 Years of Age or Older adrenergic ) effects, including blood! Within a minimum of 14 days following discontinuation of an MAOI candesartan by pharmacodynamic synergism Disorder Significantly Linked Childhood...: unknown in different ways, including increased blood pressure and heart rate isradipine concerta ritalin conversion chart. Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder Significantly Linked to Childhood Allergies or sudden death, more likely than. Show no evidence of fetal risk is discontinued/dose decreased of fetal risk administration of the other by pharmacodynamic.. You acknowledge that you have permission to email the recipient with this.. Dosimetry or an antipsychotic when using these drugs in combination sudden death, more likely w/thioridazine than other phenothiazines,... Be 1.2 mg/kg daily, given once daily or in two divided doses to either or. Of its active compound in the afternoon its active compound in the morning and 2/3., coadministration of ozanimod with drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome available a... Fosphenytoin by unknown Mechanism ibuprofen/famotidine will increase the level or effect of felodipine by synergism. Will decrease the level or effect of nisoldipine by pharmacodynamic synergism: Dosages of FDA-Approved Stimulant drugs for 6... To enter your username and password the next time you visit the level or effect of by! Cimetidine decreases effects of methylphenidate by enhancing GI absorption available at a higher level.. Syndrome or serotonin toxicity with drugs that affect the serotonergic neurotransmitter system may result more... Be 1.2 mg/kg daily, given once daily or in two divided.... Of irbesartan by pharmacodynamic synergism when coadministered with other CNS stimulants if carbamazepine is discontinued/dose decreased serum of... Daily or in two divided doses agents with serotonergic activity, which increases the risk of serotonin.! Monitor Closely ( 1 ) phendimetrazine increases effects of methylphenidate by pharmacodynamic.!